Show simple item record

dc.contributor.authorHowl, John D.en_GB
dc.contributor.authorJones, Sarahen_GB
dc.date.accessioned2013-06-27T14:55:24Z
dc.date.available2013-06-27T14:55:24Z
dc.date.issued2007
dc.identifier.citationn: Wilce, J. (Ed.), Proceedings of the 4th International Peptide Symposium, in conjunction with the 7th Australian Peptide Conference and the 2nd Asia-Pacific International Peptide Symposium, 21-25 October 2007, Cairns, Great Barrier Reef, Queensland, Australia.en_GB
dc.identifier.urihttp://hdl.handle.net/2384/294814
dc.description.abstractIntroduction: Many different cell penetrating peptides (CPPs) have been utilized as vectors to affect the highly efficient intracellular delivery of bioactive moieties. A majority of such studies employ sychnologically-organized tandem combinations of a cargo (message) and a CPP (address). To date, bioactive cargoes have included peptides, proteins and a range of oligonucleotides attached either by direct chemical conjugation or as a component of a larger macromolecular complex. Moreover, a majority of CPPs, including the commonly used sequences Tat and penetratin, are designed to be both biologically and toxicologically inert. More recently, a QSAR-based algorithm has been developed to predict cryptic polycationic CPP motifs within the primary sequences of proteins. As described here, this novel technology has enabled the study of rhegnylogic CPPs in which multiple pharmacophores for cellular penetration and desirable biological activities are discontinuously organized within the primary sequence of single peptide. This organization differs from the more commonly utilized sychnologic strategy which joins functionally discrete and continous address and messages together in a tandem construct.en_GB
dc.publisherAustralian Peptide Associationen_GB
dc.relation.urlhttp://www.peptideoz.org/proceedings.phpen_GB
dc.subjectPeptidesen_GB
dc.subjectCell Penetrating Peptides (CPP)en_GB
dc.subjectCPPen_GB
dc.subjectRhegnylogic CPPen_GB
dc.titleIdentification and biological applications of rhegnylogically-organized cell penetrating peptides.en_GB
dc.typeMeetings and Proceedingsen
refterms.dateFOA2018-02-14T10:08:14Z


Files in this item

Thumbnail
Name:
Identification and biological ...
Size:
376.8Kb
Format:
PDF

This item appears in the following Collection(s)

Show simple item record