Now showing items 1-20 of 322

    • Progress in deep sub-micron scaling for logic and memory

      Marent, Katrien; imec (LeuvenInc, 2010-12-07)
      At the International Electron Devices Meeting in San Francisco imec's advanced CMOS research program reports promising advances in scaling logic, DRAM and non-volatile memory. A new device based on non-silicon channels was realized to scale high-performance logic towards the sub-20nm node. Moreover, imec developed low-leakage capacitors allowing DRAM to be pushed to the 2x nm node. And the switching mechanism of resistive RAM for next-generation flash memories (RRAM) has been unraveled.
    • Digitoxin metabolism by rat liver microsomes@1.

      1. Crude extracts and partially purified enzyme preparations from potato tubers catalyse, at pH 5-7, the conversion of linoleic acid hydroperoxides to a range of oxygenated fatty acid derivatives. 2. 9-D- and 13-L-hydroperoxide isomers are converted at similar rates to equivalent (isomeric) products. 3. The major products from the 13-hydroperoxide isomer were identified as the corresponding monohydroxydienoic acid derivative, threo-11-hydroxy-trans12,13-epoxy-octadec-cis9-enoic acid and 9,12,13-trihydroxy-octadec-trans10-enoic acid. The corresponding products from the 9-hydroperoxide were the monohydroxydienoic acid, 9,10-epoxy-11-hydroxy-octadec-12-enoic acid and 9,10,13-trihydroxy-octadec-11-enoic acid. 4. No separation of activities forming the different products was achieved by partial purification of enzyme extracts. 5. Product formation was unaffected by EDTA, CN-, sulphydryl reagents or glutathione but was reduced by boiling the extracts. 6. This system is compared with the 9-hydroperoxide-specific enzymic formation of divinyl ether derivatives by potato extracts.
    • The metabolic benefits of different bariatric operations: what procedure to choose?

      Sudlow, Alexis; le Roux, Carel W; Pournaras, Dimitri J
      Intercritical annealing (IA) of medium-Manganese (Mn) steels is an AHSS design concept for the production of formable sheet steel. The microstructure after IA includes retained austenite (5-40 volume pct), which forms from an initial microstructure of either cold-rolled ferrite or martensite, and is stabilized to room temperature via C and Mn enrichment. Retained austenite is essential to the elevated strength-elongation, and can be engineered with equilibrium modelling and judicious selection of alloy composition and heat treatment.Long IA times (i.e. batch annealing) are expected to result in near-equilibrium microstructures with uniform Mn distributions within austenite. Relatively short IA times (<1000 s), however, may be more attractive due to energy conservation and more flexible processing routes. With shorter IA times, the phase transformation mechanism associated with austenite growth is of interest, as the sluggish diffusion of Mn in austenite is likely to result in the retention of any Mn gradients in austenite which develop during austenite growth. This thesis primarily focuses on elucidating austenite formation mechanisms during IA, and investigating the efficacy of generating Mn enrichment in austenite during relatively short IA treatments. In particular, the effect of cementite on the austenite formation mechanism, and the kinetics of Mn and carbon (C) partitioning to austenite, were investigated. Additional work focused on the effect of prior cold deformation on austenite growth and Mn redistribution during double soaking (DS) heat treatments. Scanning transmission electron microscopy with energy dispersive X-ray spectroscopy, transmission kikuchi diffraction, and field emission scanning electron microscopy were utilized for microstructural characterization, while in situ high energy X-ray diffraction, ex-situ X-ray diffraction, and dilatometry were used for bulk assessments. Phase field simulations using MICRESS®, and one dimensional diffusional simulations with the DICTRATM module of Thermo-Calc®, were also conducted for austenite formation and Mn partitioning. Austenite growth was found to be controlled predominantly by Mn diffusion. C-diffusion controlled kinetics were inhibited due to Mn enrichment in cementite, which stabilized cementite and caused dissolution to be controlled via Mn diffusion. Formation of film-like austenite from martensitic microstructures did not require the preservation of initial austenite films during heating. Phase field simulations predicted Mn-partitioning or massive transformation of austenite during DS, depending on the secondary soaking temperature. Experimental results for DS treatments were consistent with phase field simulations, which indicated that a bimodal Mn distribution can be maintained in a fully austenitic microstructure during DS treatments.
    • Pierre Pichot et ses rapports avec la psychiatrie espagnole. Notes de sa présence au Pays basque espagnol, 1993–2006

      Ezcurra, Jesus, 2020-; Gutiérrez, Miguel (Elsevier, 2018-12-31)
      Résumé Pierre Pichot est fortement lié au développement de la psychiatrie espagnole au cours de la deuxième moitié du xxe siècle. Ses rapports avec les figures les plus importantes de la vie académique espagnole sont montrés dans cette communication. Mais il s’agit surtout ici de remarquer sa présence dès 1993 et jusqu’à 2007 de façon non interrompue à Vitoria pour son cours d’Actualisation en Psychiatrie. Celle-ci constitue la réunion psychiatrique espagnole la plus ancienne, hors les congrès nationaux. Pendant les 15 séances inaugurales que Pierre Pichot développa s’étendent toute une pensée et une réflexion sur les grandes questions de la psychiatrie. Son livre La Psychiatrie à l’époque actuelle est le compendium de toutes ses conférences. Enfin l’influence de Pierre Pichot sur la psychiatrie espagnole est représentée aussi par la formation de nombreux psychiatres espagnols dans sa chaire de la Clinique de Santé mentale et de l’Encéphale. Abstract Not only is Pierre Pichot closely connected to the development of Spanish psychiatry in the second half of the 20th century, but is known for his ties with the most significant people in the Spanish academic world. As an expert in Spanish history, he maintains a close relationship with Hispanists in France, which makes him a reference in Spanish psychiatry. However, our intention is to highlight his uninterrupted presence from 1993 until 2006 to inaugurate the Psychiatric Convention in Vitoria on the latest psychiatric developments. At present this Congress is the longest – lasting gathering of experts in Psychiatry in Spain apart from the National Yearly Congress of Psychiatry. During these 15 inaugural conferences presented by Pichot, one can find a complete thought and reflection on the important questions and debates in Psychiatry. His book, Present Day Psychiatry, is a compendia of each one of his presentations. The studies found in this work do not shy away from the most controversial topics. Pierre Pichot's rigour of psychiatric thought is initially found in the 60s with the publication of Los Test Mentales. As has been previously pointed out, this text replaced the Pieron Tratado. Undoubtedly, Pichot is the one to whom today's psychologists and psychiatrists owe the advance of psychometry in dealing with mental pathology. In the best sense of the word Pichot was an eclectic, capable of dealing with topics of interest from a wide range of perspectives. Therefore, he reflected on psychotherapy and to need to avoid sectarianism in schools, which is so closely related to present day efforts to spread and insure psychotherapeutic trading for psychiatric professionals. This, in this article we will summarize some of the contributions Pichot carried out in his presentations while he attended the congresses in Vitoria for 15 years. The first contribution to be covered is the evolution of the concept of affective disorders. This is proof of how week he was familiar with the semiological evolution itself concerning this matter. In addition, the term, psychosis and its lack of clarity will be dealt with. This will provide the opportunity to later continue on with the history of severe psychotic disorder and the influence Pichot holds as a representative of the French school for the autonomous inclusion of severe psychotic disorder in DSM-III and above all in CIE-10. Pichot does not shy away from the debate on the medical discipline to which the treatment of Alzheimer's belongs. In his opinion the discovery of cerebral lesions from Alzheimer's is not a decisive argument to include Alzheimer's or any mental disorder in the field of neurology. Finally and beyond all that is the importance of Pichot as the one who introduced DSM-III in Europe, which definitely makes him worthy to form part of Psychiatry itself in Europe. Without a doubt, Pichot forms part of a line of psychiatrists who have changed everything, who defined what mental illness was as well as what a psychiatrist was. Together with the group from Washington University in Saint Louis, Pichot dealt with the question of diagnosis in a rational way, far from the unclear way of DSM-II. The contribution of all those men and women to modern Psychiatry is fundamental to the history of our specialization.
    • Assessment of the Injection Performance of a Tapered Needle for Use in Prefilled Biopharmaceutical Products

      Fukuhara, Ayano; Uchiyama, Susumu; Elena, Krayukhina (Elsevier, 2020-01-31)
      The design of injection devices, including prefilled syringes (PFSs) and autoinjectors, requires an understanding of the optimization of injection conditions. The injection of highly concentrated biopharmaceuticals can lead to exceptionally high injection forces, due to their high viscosity. To overcome this challenge, a tapered needle has been recently developed by Terumo Corporation. In the present study, we measured the injection forces in PFSs equipped with 24G-29G tapered needle (29G TNN), 27G thin-wall needle (27G TW), and 29G TW using several model and pharmaceutical protein solutions. The injection forces measured in the 29G TNN PFSs were lower than those in 29G TW for all solutions, similar to those in 27G TW PFSs for Newtonian solutions, and were lower than those in the 27G TW PFSs for non-Newtonian solutions which demonstrated shear-thinning behavior. No significant changes in aggregates or micron-size particle concentrations were observed upon injection, regardless of the needle type. Mathematical modeling supported the experimental findings that under similar flow rate conditions injection pressure in a tapered needle is lower than that in a cylindrical needle. Our results indicate that there are advantages of using tapered needles for the injection of biopharmaceutical formulations particularly those showing shear-thinning behavior.
    • Comparisons of early vascular reactions in biodegradable and durable polymer-based drug-eluting stents in the porcine coronary artery

      Ijichi, Takeshi; Nakazawa, Gaku; Torii, Sho; Nagamatsu, Hirofumi; Yoshikawa, Ayako; Souba, Junko; Isobe, Atsushi; Hagiwara, Hitomi; Ikari, Yuji (Public Library of Science (PLoS), 2019-1-10)
    • Introduction: Property and Language, or, the Ghost of the Fifth Panel

      Rose, Carol M.
      It is gratifying, hugely flattering, and at the same time somewhat embarrassing to have to open a conference and then a symposium issue on one's own academic work. No doubt understanding this embarrassment, my colleague and good friend Ian Ayres suggested a way out: since the conference was named "The Properties of Carol Rose," I should take the occasion to talk about the various residences I have owned. A great idea, and I did indeed think about it, because as Ian knows, I have had good luck in that dimension, with more than my share of weird and interesting addresses. But as intriguing as Ian's idea would have been, there was really another topic altogether that I thought I should address at the opening of the conference and now this symposium issue. That topic is the Missing Fifth Panel, or as I will sometimes call it in this Introduction, the Ghost Panel.
    • The Rose Theorem?

      Heller, Michael
      Law resists theorems. We have hypotheses, typologies, heuristics, and conundrums. But, until now, only one plausible theorem - and that we borrowed from economics. Could there be a second, the Rose Theorem? Any theorem must generalize, be falsifiable, and have predictive power. Law's theorems, however, seem to require three additional qualities: they emerge from tales of ordinary stuff; are named for, not by, their creators; and have no single authoritative form. For example, Ronald Coase wrote of ranchers and farmers. He has always shied away from the Theorem project. When later scholars formalized his parable, they created multiple and inconsistent versions. Likewise, Carol Rose writes rich narratives of maypoles and foxes, rivers and roman roads. She offers a theory of human motivation and predictions about our behavior. And we may ask, though she might not, whether the rich alluvial mud of her scholarship crystallizes into a Rose Theorem.
    • Oysters, Ecosystems, and Persuasion

      Rieser, Alison
      In his essay on the commons scholarship of Carol Rose, Michael Heller deploys an epoch-spanning synopsis of Western society's passion for the oyster to make his case for a Rose theorem. Professor Heller posits that the work of Carol Rose sets out a testable theory: law emerges from and is shaped by the interactions of human culture with nature and natural resources. The oyster's survival across the ages, he suggests, is due to this process, a "constantly shifting matrix of strategies, simultaneously public and private, individual and community, and on their constant renegotiation and interpolation." Professor Heller's is indeed an engaging account, and he is certainly correct that the oyster's story challenges the neoclassical economic account of the evolution of property rights. But as an account of what the oyster's story contributes to our ideas about common resources, it is incomplete. And Heller surely has not gone far enough in looking at the scholarship of Carol Rose from the point of view of the oyster. By failing to bring the story into the twenty-first century, Heller misses most of what the oyster's story tells us about human institutions.
    • Re-crafting a Public Domain

      Lessig, Lawrence
      There is a public domain, but it is small, relative to its history, and it is shrinking. Digital technology will only speed its decline. And because most are oblivious to the particular threat that digital technology poses for the public domain, the prospects for reversing this trend are not promising. On the present path, the idea of the public domain will be as familiar to our children as the intergovernmental tax immunity doctrine is to our students. This loss of the public domain, properly understood, will be a profound loss for freedom and culture, or more precisely, free culture. It will also be persistent. For the mechanisms that will effect the elimination of this domain are not merely legal doctrines. The mechanisms are machines protected by the most powerful (if delicate) technologies of control that man has devised. My aim in this essay is to frame a way of talking about this public domain, and to map a strategy for its defense. The defense will come both from rebuilding the public domain, properly understood, and from crafting an "effective" public domain-meaning a free space that functions as a public domain, even though the resources that constitute it are not properly within the public domain.
    • Property and the Public Domain

      Dagan, Hanoch
      Friends of the public domain are typically suspicious of property-talk. Property is perceived as the foe, epitomizing the threat of a shrinking public domain. This common view is misguided; it is also unfortunate. It is misguided because the cleavage between property discourse and a thriving public domain is largely illusory. It is unfortunate because the concept of property has enormous rhetorical power in shaping people's expectations and therefore in the construction of what they deem normal, obvious, and thus clearly justified. For both reasons, friends of the public domain should embrace property, rather than fight it. Lawrence Lessig's work epitomizes the suspicion of public domain advocates towards property. In Re-crafting a Public Domain Lessig laments the expanding rights of copyright holders to preclude others from using cultural artifacts and offers strategies for reversing the tide. Lessig claims that once classified as property, copyright is burdened by "the ordinary view about property" which is "binary at its core." He believes that notwithstanding lawyers' understanding of property as a bundle of rights, the propertization of creative activity facilitates a social ecology in which you must secure permission before your use. This ecology (alongside the powerful interest groups supporting it) accounts for Lessig's pessimism about the possibility of a happy legal reform. It also explains his apologetic response to critics of the attempt to encourage authors to opt into a system where only some of the rights copyright secures are typically reserved. Neither the pessimism nor the apologia is warranted. Nothing in the language of property necessarily invites the agenda of the content industry. Quite the contrary: the form, the substance, and the history of property convey lessons that are rather helpful to the goal, which I share, of re-crafting the public domain. By neglecting these lessons, guardians of the public domain allow copyright expansionists to capture the powerful brand-name of property, thus undermining their very own cause.
    • Thirst: A Short History of Drinking Water

      Salzman, James
      Nestled in the Andes, the Bolivian city of Cochabamba lies in a fertile valley astride the banks of the Rocha River. Bolivia is the poorest country in South America, with two-thirds of its population below the poverty line. As in many developing countries, over forty percent of Cochabamba's 800,000 residents lack access to a water supply network. And even those who do have pipes cannot depend on reliable service. The poor often live in squatter settlements on the outskirts of town, relying for their drinking and domestic water supplies on private vendors. In a cruel irony, the poorest end up paying much more for their water than wealthier citizens connected to the city's water mains. As part of a nationwide project to improve provision of municipal services, the government of Bolivia launched a major privatization reform effort in the late 1990s. Prompted by financial institutions such as the International Monetary Fund and World Bank, the Bolivian government actively sought out private investor management for Cochabamba's water and sewage services. Treating drinking water as a priced good under private management, it was widely argued, would improve the water supply system infrastructure and delivery by injecting much-needed capital, greater efficiencies, and increased attention to customer needs. A forty-year concession for water and wastewater services in Cochabamba was granted to an international private consortium headed by Bechtel and known as Aguas del Tunari. In the national law passed to facilitate this transaction, water was declared the property of the state, available for licensing to private companies for distribution.
    • Let Us Drink Our Fill: The History of Water and Its Impact on Resource and Environmental Management

      Flatt, Victor B.
      Jim Salzman's Thirst. A Short History of Drinking Water tells a remarkable story about how we have managed one of the most important substances in our lives, and through its historical tales, may also point to a way to think not only about water management, but also about the management of all kinds of resources - a management strategy that is not defined by the resource, but instead, the resource's ultimate use. Up until this time, those who study environmental pollution have generally focused on resource management (and in this I include resources that can be despoiled by pollution, such as clean air) based on the resource itself, i.e. how should we best manage water, or air, or animals, or land generally. With many of these natural resources, management strategies have been driven by concerns of common overuse - the tragedy of the commons. Thus, much of the legal analysis of resource use has focused on how to correct the commons problem so that we all get appropriate economic signals to avoid overuse. In the environmental law arena, the market's failure to internalize costs, which results in the tragedy of the commons, is given as the main justification for government intervention into the private marketplace - we have to control how much pollution one can put into the commons because the polluters have no incentive to do so themselves. We have to choose the best management strategy to correct this market problem. Many of us have grappled with theories of which kind of intervention would best correct the overuse of resources. One of the most important contributors to this field is Professor Carol Rose, who has analyzed various methods of pollution-control strategies and drew conclusions about intervention choice based on the overall pressure faced by a resource. Importantly, she focused us not just on the effect a strategy would have on the resource itself, but its costs for the regulated community and costs for the government to enforce the strategy.
    • Crystals and Mud in Nature

      Lazarus, Richard J.
      Professor James Salzman has written a wonderful article, which promises an equally wonderful book. His article intelligently and thoughtfully examines the forces that compete, conflict, and combine in the creation of laws relating to drinking water. These include, of course, the physical characteristics of the resource itself and how the resource relates to essential biological needs of humankind. But as Professor Salzman demonstrates, the biological role is only one of several perspectives on drinking water relevant to the kind of legal rules that apply to it. The article describes drinking water as a cultural resource, a social resource, and an economic resource, contending that one has to consider each of these various "natures" of a natural resource to determine how best to fashion legal rules governing its management. The article readily reminds us how much human history and culture relates to natural resources law. For the purposes of this commentary, however, I would like to expand on two reactions I had to the article. The first is that the article's narrow focus on one use of water undermines some of the article's conclusions by understating water's complexity. And the second is why the article made me think about dirt, and ultimately about mud, and the juxtaposition of water and dirt in natural resources law.
    • Tribute to Carol Rose

      Been, Vicki
      It is a great honor to be asked to pay tribute to Carol Rose, whose work has been critically important to my own scholarship and to that of so many of my peers. Carol has been an inspiration to several generations of scholars, not only because of the many keen insights she has contributed to several different fields of law, but also, perhaps especially, because of her style of thinking, writing, and working with other scholars. Carol's modesty, her incredible ability to cut right to the heart of the matter in the most down-to-earth, but always amazingly well-turned phrase, and her generosity to other scholars are models of what a more engaged, more honest, and more gracious scholarly community could be. Carol likes to organize things in lists-her articles include a dozen propositions on property and takings, seven arguments on property, and so on. I am going to offer, then, a list of the top three reasons that Carol's contributions to the "vastly overwritten" takings literature, to use her phrase, are genuine advances of a very special sort. In the hope of spurring Carol to develop her contributions into a more comprehensive theory about how to ensure that government acts efficiently and fairly when regulating property, I am then going to propose the outline for what I hope will be her book on takings.
    • Visions of Guadalupe: Traces of the Ghost Panel

      Torres, Gerald
      Professor Rose remarked that she wished that a panel on her contributions to narrative theory had been included in this symposium. Since that work is lurking in the background, Professor Rose suggested that it is really a ghost panel. Professor Been did an excellent job of synthesizing Carol's work on takings, ultimately proposing that Professor Rose write a book about takings using her journal articles as feedstock for that book. I have little to add to Professor Been's analysis of Professor Rose's work on takings. Instead, my remarks will look at her contribution to the takings literature through the lens of her contribution to narrative theory. I think that understanding Carol's contribution to narrative theory and law is actually quite important to fully appreciating her contribution to the takings debate. It is the confluence of these two streams of thought in Carol's work that makes her work so significant. I will organize my remarks around a central observation that may be more or less controversial, but which I regard as obvious as a pig in a parlor. About a generation ago it became clear that the macro-social debates over the architecture of our social life would get played out through arguments about property and property rights in a way that those debates were previously played out in the civil rights movement using the equal protection and commerce clause. I am not suggesting that the struggle over the meaning of the civil rights movement is over, but that a new front was opened in an effort to limit legitimate government action. This challenge to governmental action would get articulated through the Takings and Due Process Clauses of the Constitution. The activists in this story identified themselves as defenders of property rights. Their movement has come to frame both the popular and legal debates about the nature of property and the proper role of government in regulating social life.
    • The Just and the Wild

      Underkuffler, Laura S.
      The question of the extent to which previously recognized property rights should continue to be protected has undoubtedly bedeviled every legal system that has attempted to address it. On the one hand, the legal idea of property reflects a broad societal commitment to the continued honoring of historically based entitlements on which individuals depend. On the other hand, every complex society is acutely aware of the inadequacy of the simple idea of the legal protection of existing rights as a response to human poverty, environmental degradation, and other critical problems. This issue of who has what - or who can count on what - is at the heart of the American takings problem. Our feelings and fears about poverty, wealth, preservation, and change fuel legal and political battles over the question of the taking of property by government. Property is seen as a bulwark which protects individual wealth, liberty, and autonomy. Whether government can impair this bulwark - without recognizing that impairment-implicates, on the deepest levels, our fundamental feelings of security. Because of the complexities and extraordinarily high stakes in this field, it presents particular fascinations and minefields for scholars. It is difficult to give useful advice about takings law without oversimplifying the issues or short changing our own, conflicting emotions. In its efforts in this task, the work of Professor Carol Rose is without peer. It is (at the same time) intellectually profound, meticulously balanced, practically useful, and boldly and provocatively passionate.
    • First Amendment Bargains

      Ayres, Ian Ayres
      Before starting formally, let me pause to say that it is quite an honor to participate in this celebration. When I think of the properties of Carol Rose, I think first of her laugh. It is a wonderfully exuberant cackle which, when in full bloom, often causes her head to tilt slightly back. She has a way of laughing after delivering a tangy barb that somehow diffuses the sting. I know it's not possible, but sometimes I hear her laugh when I'm reading her footnotes. This laugh is a great pedagogical gift. When Carol was teaching me property in, I believe, the fall of 1985, she would occasionally cold-call students in the very large class that filled Room 127. One day, Carol looked down at her class roster and called on my classmate Lisa Allred for the first time. Lisa was not prepared, or at least was not prepared to speak, and thought she would try to hide out in the masses and simply not respond, with the hope that Carol would think she wasn't in class that day. But Carol turned and looked at Lisa and said "Isn't that yoooouuu?" There was a scared silence in the class. And then Carol laughed. It was not a mean laugh, it was so full of sincere joy that it was very hard not to be pulled along. I've been lucky to hear this same laugh many times over the yearsoften just after Carol has skewered a speaker with some particularly deflating retort. "Socrates, Shmocrates," she said in response to Robert Frank's Winner-Take-All theory. As Carol moves west, I'm going to miss the chance to hear her laugh.
    • Commodification and the Media

      Banner, Stuart
      I met Carol many years before Carol met me. In the fall of 1986 when I was starting my second year of law school I signed up to work on the law review, and my very first assignment was to check the accuracy of the footnotes in a manuscript called Crystals and Mud in Property Law. I wish I could say that Crystals and Mud changed my life, but that would be putting it too strongly. It did nudge my life in a new direction a little bit, though. I didn't know anything about what law professors wrote. I had been through a year of law school, and I had read lots of those edited opinions in casebooks, so I guess I must have expected scholarship to be the same - kind of boring, in that pugnacious harrumphing lawyerly style. Of course Crystals and Mud turned out to be exactly the opposite. It was fascinating stuff, but for me the main thing wasn't the substance but the style. It was written in the voice of a person you'd actually want to meet, someone who wasn't trying to win an argument at all costs, but rather a person who was clearly amused by the people and the events she was describing but who at the same time retained enough empathy for them and their predicament to want to understand why they did what they did. I wanted to write like this mysterious Carol Rose. And that's what I've been trying to do ever since.
    • The Elasticity of Contract

      Ertman, Martha M.
      It is not surprising that Carol Rose began this conference reflecting that she has spent her career looking at the importance of the language we use to explore property, since she is famous for explicating complexity through wonderfully simple, disarming language. Stuart Banner's observation that Professor Rose is one of the few people who speak two languages fluently and are taken as a native in both cultures nicely captures the way her work also bridges communitarianism and legal economic discourse.